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Paroxysmal Tonic Upgaze:a Reappraisal of Outcome Ann Neurol 43:514-520, Hayman,M.,et al, 1998 See this aricle in Pubmed Article Abstract Paroxysmal tonic upgaze(PTU)of childhood is a distinctive neuro- ophthalmological syndrome of unknown etiology and pathogenesis that is characterized by episodes of sustained upward deviation of the eyes,often with incomplete downward saccades on attempted downgaze.It is generally regarded as having a benign outcome.We observed 16 children with PTU,from 10 months to 11 years from onset(mean 5.4 years),to study the natural history and possible etiology.Five cases were from two unrelated families. Onset of PTU occurred either during or after an intercurrent infection or vaccination in 5 children.No antecedent was identifiable in the rest.PTU had completely resolved in 10 children(62%)(mean age at offset,2.5 years) whereas 2 children intermittently manifest a modified form of the disorder.At followup,11 children(69%)had developmental delay,intellectual disability or language delay and 9(56%)had ocular motility problems other than PTU.Only 3 children(19%)had normal development and neurological findings.PTU is a heterogeneous syndrome with respect to associations and outcome and may simply be an age-dependent manifestation of a variety of disorders affecting corticomesencephalic control of vertical eye movement. This disorder may be an early sign of more widespread dysfunction.

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(click to filter results - removes previous filter) children eye movement,disorders of neuroophthalmology ocular motility,disorders of paroxysmal neurologic deficits paroxysmal tonic upgaze prognosis review article transient neurologic deficit upgaze upgaze,sustained

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